Nafamostat Impurity 12 CAS 82956-09-0(Free Base)
| CAS No. | 82956-09-0(Free Base) |
| Molecular Formula | C19H17N5O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Nafamostat Impurity 12 (CAS 82956-09-0(Free Base)) is a certified pharmaceutical impurity reference standard with the molecular formula C19H17N5O2C2HF3O2CH4O3S and a molecular weight of 557.50 g/mol.
Nafamostat Impurity 12 (C19H17N5O2C2HF3O2CH4O3S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C19H17N5O2 C2HF3O2 CH4O3S |
| Molecular Weight | 557.50 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Nafamostat Standards
- Nafamostat Impurity 61 (CAS 1026613-65-9)
- Nafamostat impurity 110 (CAS 107490-62-0)
- Nafamostat Impurity 65 (CAS 107490-62-0（free base）)
- Nafamostat Impurity N3 (CAS 115325-88-7)
- Nafamostat Impurity 26 (CAS 1192026-58-6)
- Nafamostat Impurity 63 (CAS 121714-82-7)
- Nafamostat Impurity 37 (CAS 122228-09-5)
- Nafamostat Impurity 35 (CAS 130200-58-7)
Recommended Standards
- Posaconazole Impurity 97 (CAS 182210-71-5)
- Roxadustat Impurity 19 (CAS CATO-C4X-221319)
- Ganciclovir EP Impurity D (CAS CATO-C4X-10214)
- Naproxen Impurity 45 (CAS CATO-C4X-170845)
- Donepezil-d5 (CAS 1128086-25-8)
- N,N'-Bis(2-pyridylmethyl)-1,2-ethylenediamine tetrahydrochloride dihydrate (CAS 1310544-60-5)
- Methyl 3-bromo-5-ethyl-2-fluorobenzoate (CAS 2092488-94-1)
- 2-Naphthyloxyacetamide (CAS 35368-77-5)
- 2-Methoxy-3,5-dimethylbenzene-1-sulfonyl chloride (CAS 749268-53-9)
- Insulin Degludec Impurity 19 (CAS CATO-C4X-215719)
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